New research indicates that individuals who discontinue new slimming jabs like semaglutide or tirzepatide can put back on reduced body mass much more quickly than those who end conventional lifestyle regimens.
Findings released in a leading health publication points out that while obese individuals often shed substantial amounts of their total mass while using the jabs, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing such treatments should be aware of the danger of rapid rebound weight gain when the medication concludes," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to pre-treatment mass within about 18 months.
Comparing Therapies
The research, which looked at 37 of studies involving over 9,000 of participants, compared the effects of the injectable medications with older methods.
Scientists emphasize that individuals who lose weight through lifestyle changes alone usually have a less rapid weight regain—perhaps 0.1 kg a month—post-intervention.
Understanding the Fast Rebound
Nutrition scientists propose the mode of action of the jabs explains the accelerated rebound.
These medications mimic a natural hormone called GLP-1, which moderates appetite.
"Artificially providing the hormone levels several times higher than normal could lead to the system to generate a reduced amount of its own natural hormone, and could lessen sensitivity to its effects," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this GLP-1 'fix' means appetite is no longer kept in check, making binge eating much more probable."
A Chronic Disease?
Health authorities suggest the jabs for people with obesity-related health risks, alongside recommended lifestyle changes.
Many experts argue that, given the significant potential of relapse, the treatment might need to be long-term.
This opinion is echoed by pharmaceutical companies, who note that the results "emphasize the long-term character of obesity," similar to managing conditions like high blood pressure.
User Accounts
Individuals who have discontinued the jabs report a powerful resurgence of cravings.
"It felt as if a switch flipping and I was suddenly starving," described one woman.
This difficulty is exacerbated if patients have not established sustainable lifestyle or habit changes during treatment.
Widespread Interest
Figures indicate that a significant number of adults in the UK have used these injections in the past year, with desire continuing to grow.
- Use is higher among females than males.
- The 40s and 50s demographic shows the greatest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Finally, researchers stress that while these medications are potent agents for weight loss, they are not a standalone solution and lasting health benefits relies on combined behavioural changes.
